Oral Presentation 11th Australian Peptide Conference 2015

Peptides with a polymer coat: Self-assembled nanotubes (#61)

Katrina A. Jolliffe 1
  1. The University of Sydney, Sydney, NSW, Australia

The self-assembly of beta-sheet forming cyclic peptides has emerged in recent years as a remarkably versatile approach to the formation of organic nanotubes with a well-defined internal diameter. Such structures have a range of potential applications but their use is hindered by low solubility and an inability to control tube length.1 We have developed several synthetic approaches that enable efficient polymer conjugation to cyclic peptides, providing excellent control over the number and type of polymer chains that can be appended and hence the solubility of the conjugates. The synthesis, self-assembly properties and some applications of cyclic peptide-polymer conjugates of this type will be presented.2

  1. Chapman, R.; Danial, M.; Koh, M. L.; Jolliffe, K. A.; Perrier, S. Chem. Soc. Rev., 2012, 41, 6023.
  2. Danial, M; Tran, C. M. N.; Young, P. G.; Perrier, S; Jolliffe, K. A. Nature Commun., 2013, DOI: 10.1038/ncomms3780; Chapman, R.; Koh, M. L.; Warr, G. G.; Jolliffe, K. A.; Perrier, S., Chem. Sci., 2013, 4, 2581-2589; Chapman, R.; Warr, G. G.; Perrier, S.; Jolliffe, K. A. Chem. Eur. J., 2013, 19, 1955; Chapman, R.; Jolliffe, K. A.; Perrier, S., Adv. Mater., 2013, 25, 1170.